相互作用
Amobarbital + Avapritinib
重症度: 重大
Amobarbital and Avapritinib: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Amobarbital may induce CYP3A4 and markedly lower avapritinib exposure. This could cause loss of antitumor efficacy.
この相互作用をわかりやすく説明すると
Amobarbital and Avapritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Avapritinib belongs to Oncology.
なぜ起こるのか
Barbiturate induction of CYP3A4 increases avapritinib metabolism.
対処法
Avoid concomitant strong or moderate CYP3A4 inducers, as labeling recommends. Use an alternative sedative.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmobarbitalとAvapritinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amobarbitalのその他の相互作用
Avapritinibのその他の相互作用
よくある質問
Can I take Amobarbital with Avapritinib?
MediHelp rates the interaction as major. Amobarbital and Avapritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital may induce CYP3A4 and markedly lower avapritinib exposure. This could cause loss of antitumor efficacy.
How serious is the interaction between Amobarbital and Avapritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant strong or moderate CYP3A4 inducers, as labeling recommends. Use an alternative sedative.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
