相互作用
Avatrombopag + Secobarbital
重症度: 中等度
Avatrombopag and Secobarbital: moderate interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Secobarbital induces CYP3A4 and may induce CYP2C9, which can lower avatrombopag exposure and reduce the platelet response.
この相互作用をわかりやすく説明すると
Avatrombopag and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avatrombopag belongs to Miscellaneous; Secobarbital belongs to Central Nervous System.
なぜ起こるのか
Induction of CYP3A4 and CYP2C9 increases avatrombopag clearance.
対処法
Monitor platelet counts and follow the labeled dose increase for ITP when combined with inducers. Reassess the dose when the barbiturate is stopped.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AvatrombopagとSecobarbitalの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Secobarbitalのその他の相互作用
Avatrombopagのその他の相互作用
よくある質問
Can I take Avatrombopag with Secobarbital?
MediHelp rates the interaction as moderate. Avatrombopag and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital induces CYP3A4 and may induce CYP2C9, which can lower avatrombopag exposure and reduce the platelet response.
How serious is the interaction between Avatrombopag and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and follow the labeled dose increase for ITP when combined with inducers. Reassess the dose when the barbiturate is stopped.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
