相互作用
Amiodarone + Avatrombopag
重症度: 中等度
Amiodarone and Avatrombopag: moderate interaction.
最終更新日
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概要
Amiodarone inhibits CYP3A4 moderately and may raise avatrombopag exposure. Higher exposure can increase the platelet count response and the risk of thrombotic events.
この相互作用をわかりやすく説明すると
Amiodarone and Avatrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Avatrombopag belongs to Miscellaneous.
なぜ起こるのか
Inhibition of CYP3A4 (and possibly CYP2C9) metabolism of avatrombopag by amiodarone.
対処法
Follow avatrombopag labeling for a reduced starting dose with moderate dual CYP2C9/3A4 inhibitors in ITP. Monitor platelet counts and adjust the dose accordingly.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmiodaroneとAvatrombopagの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amiodaroneのその他の相互作用
Avatrombopagのその他の相互作用
よくある質問
Can I take Amiodarone with Avatrombopag?
MediHelp rates the interaction as moderate. Amiodarone and Avatrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits CYP3A4 moderately and may raise avatrombopag exposure. Higher exposure can increase the platelet count response and the risk of thrombotic events.
How serious is the interaction between Amiodarone and Avatrombopag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow avatrombopag labeling for a reduced starting dose with moderate dual CYP2C9/3A4 inhibitors in ITP. Monitor platelet counts and adjust the dose accordingly.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
