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Avatrombopag

Avatrombopag is a medicine in the class miscellaneous. It is used for thrombocytopenia.

最終更新日 出典: EMA SmPC, US FDA label

医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。

このページの臨床コンテンツは英語でのみ提供されています。

要点

薬効分類
Miscellaneous
一般的な剤形
錠剤
一般的な規格
20 mg, 10 mg
既知の相互作用
12 (中等度: 11 · 軽度: 1)
商品名
4
国・市場
3

剤形、規格、商品名は国によって異なります。お手元の製品をご確認ください。

何に使われるか

作用のしくみ

Orally bioavailable small molecule TPO receptor agonist that stimulates proliferation and differentiation of megakaryocytes from bone marrow progenitor cells, increasing platelet production. It does not compete with TPO for receptor binding and has an additive effect with TPO.

成人の通常用量（添付文書の要約）

Thrombocytopenia in chronic liver disease before a procedure (tablets): platelet count less than 40×10 9 /L: 60 mg (3 tablets) orally once daily for 5 days, starting 10 to 13 days before the procedure

添付文書の最初の用法・用量の行のみの要約です。用法・用量の全項目はアプリでご覧いただけます。

妊娠と授乳

妊娠
Unknown Animal studies showed miscarriage in rabbits and pup deaths in rats at high exposures; human data are insufficient. May cause fetal harm. Use only if benefit outweighs risk and inform the patient of the potential risk.
授乳
Unsafe No human milk data; present in rat milk. US label: do not breastfeed during treatment and for at least 2 weeks after the last dose; after a short pre-procedure course, pump and discard milk for that period.

報告されている副作用

  • Pyrexia
  • Abdominal pain
  • Nausea
  • Headache
  • Fatigue
  • Contusion

禁忌

  • None.

注意が必要な方

  • Thrombotic/thromboembolic complications: TPO receptor agonists are associated with thrombotic and thromboembolic events; monitor platelet counts and for signs of thromboembolism, and treat promptly.
  • Consider increased thrombotic risk in patients with known risk factors, including genetic prothrombotic conditions and acquired factors such as antiphospholipid syndrome.
  • Do not use to normalize platelet counts.

妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。

主な相互作用 (12)

All 12 interactions, with severity and what to do

Pro+会員向け

ページ全体を見る

アカウントを作成してPro+トライアルを始めると、Avatrombopagの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。

  • Dosing by age, kidney and liver function, and further dose lines
  • Renal and hepatic dose adjustments
  • Paediatric dosing
  • Dosing in older adults
  • How to give it
  • Pharmacokinetics
  • Patient counselling points
  • Food interactions
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同じ分類のほかの薬剤

よくある質問

What is Avatrombopag used for?

Avatrombopag is a medicine in the class miscellaneous. It is used for Thrombocytopenia, Thrombocytopenic purpura.

What side effects have been reported with Avatrombopag?

Pyrexia, Abdominal pain, Nausea, Headache, Fatigue, Contusion.

Can Avatrombopag be taken in pregnancy or while breastfeeding?

Pregnancy: Unknown. Animal studies showed miscarriage in rabbits and pup deaths in rats at high exposures; human data are insufficient. May cause fetal harm. Use only if benefit outweighs risk and inform the patient of the potential risk. Breastfeeding: Unsafe. No human milk data; present in rat milk. US label: do not breastfeed during treatment and for at least 2 weeks after the last dose; after a short pre-procedure course, pump and discard milk for that period.

What does Avatrombopag interact with?

MediHelp lists 12 known interactions for Avatrombopag. Moderate: 11 · Minor: 1. The most serious include Amiodarone, Amobarbital, Bosentan.

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