相互作用
Axitinib + Rifabutin
重症度: 重大
Axitinib and Rifabutin: major interaction.
最終更新日
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概要
Rifabutin induces CYP3A4 and may substantially lower axitinib concentrations, reducing efficacy. The effect is expected to be less than with rifampicin but is still clinically relevant.
この相互作用をわかりやすく説明すると
Axitinib and Rifabutin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Axitinib belongs to Oncology; Rifabutin belongs to Anti Bacterial.
なぜ起こるのか
Rifabutin induces CYP3A4 and CYP1A1 pathways, increasing axitinib clearance.
対処法
Avoid concomitant use where possible and select an agent with no enzyme-inducing potential. If it is unavoidable, monitor response and consider a gradual axitinib dose increase.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AxitinibとRifabutinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Axitinibのその他の相互作用
Rifabutinのその他の相互作用
よくある質問
Can I take Axitinib with Rifabutin?
MediHelp rates the interaction as major. Axitinib and Rifabutin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifabutin induces CYP3A4 and may substantially lower axitinib concentrations, reducing efficacy. The effect is expected to be less than with rifampicin but is still clinically relevant.
How serious is the interaction between Axitinib and Rifabutin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use where possible and select an agent with no enzyme-inducing potential. If it is unavoidable, monitor response and consider a gradual axitinib dose increase.
What other medicines interact with Axitinib?
MediHelp also lists interactions of Axitinib with, for example, Amobarbital, Apalutamide, Atazanavir. The full list is on the Axitinib page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
