相互作用
Apixaban + Rifabutin
重症度: 重大
Apixaban and Rifabutin: major interaction.
最終更新日
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概要
Rifabutin induces drug-metabolising enzymes and speeds up clearance of apixaban. Reduced apixaban exposure leaves patients less protected against stroke or venous thromboembolism.
この相互作用をわかりやすく説明すると
Apixaban and Rifabutin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apixaban belongs to Cardiovascular; Rifabutin belongs to Anti Bacterial.
なぜ起こるのか
CYP3A4/P-gp induction lowers apixaban exposure
対処法
Avoid with potent inducers; if essential, monitor for thrombosis and consider an alternative anticoagulant.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ApixabanとRifabutinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Apixabanのその他の相互作用
Rifabutinのその他の相互作用
よくある質問
Can I take Apixaban with Rifabutin?
MediHelp rates the interaction as major. Apixaban and Rifabutin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifabutin induces drug-metabolising enzymes and speeds up clearance of apixaban. Reduced apixaban exposure leaves patients less protected against stroke or venous thromboembolism.
How serious is the interaction between Apixaban and Rifabutin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid with potent inducers; if essential, monitor for thrombosis and consider an alternative anticoagulant.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
