相互作用
Lorlatinib + Rifabutin
重症度: 併用禁忌
Lorlatinib and Rifabutin: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Rifabutin induces CYP3A4 and can lower lorlatinib exposure, risking loss of efficacy. Strong CYP3A inducers given with lorlatinib have been associated with raised liver enzymes. Labeling prohibits the combination.
この相互作用をわかりやすく説明すると
Lorlatinib and Rifabutin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lorlatinib belongs to Oncology; Rifabutin belongs to Anti Bacterial.
なぜ起こるのか
CYP3A4 induction increases lorlatinib metabolism and lowers its plasma concentration.
対処法
Do not use together; choose a non-inducing alternative for the indication. If an inducer is necessary, stop it for about 3 half-lives before lorlatinib.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LorlatinibとRifabutinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Lorlatinibのその他の相互作用
Rifabutinのその他の相互作用
よくある質問
Can I take Lorlatinib with Rifabutin?
MediHelp rates the interaction as contraindicated. Lorlatinib and Rifabutin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifabutin induces CYP3A4 and can lower lorlatinib exposure, risking loss of efficacy. Strong CYP3A inducers given with lorlatinib have been associated with raised liver enzymes. Labeling prohibits the combination.
How serious is the interaction between Lorlatinib and Rifabutin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose a non-inducing alternative for the indication. If an inducer is necessary, stop it for about 3 half-lives before lorlatinib.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
