相互作用
Balsalazide + Voclosporin
重症度: 中等度
Balsalazide and Voclosporin: moderate interaction.
最終更新日
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概要
Voclosporin is a calcineurin inhibitor that is nephrotoxic. Mesalamine-type drugs such as balsalazide have rarely been associated with interstitial nephritis and renal impairment, so the renal risk may be additive.
この相互作用をわかりやすく説明すると
Balsalazide and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Balsalazide belongs to Gastrointestinal Tract; Voclosporin belongs to Miscellaneous.
なぜ起こるのか
Additive nephrotoxic potential through different mechanisms (calcineurin inhibitor hemodynamic effect and mesalamine interstitial nephritis).
対処法
Monitor serum creatinine and eGFR at baseline and regularly during combined use. Reduce the voclosporin dose or stop the agents if renal function declines.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BalsalazideとVoclosporinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Balsalazideのその他の相互作用
Voclosporinのその他の相互作用
よくある質問
Can I take Balsalazide with Voclosporin?
MediHelp rates the interaction as moderate. Balsalazide and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin is a calcineurin inhibitor that is nephrotoxic. Mesalamine-type drugs such as balsalazide have rarely been associated with interstitial nephritis and renal impairment, so the renal risk may be additive.
How serious is the interaction between Balsalazide and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and eGFR at baseline and regularly during combined use. Reduce the voclosporin dose or stop the agents if renal function declines.
What other medicines interact with Balsalazide?
MediHelp also lists interactions of Balsalazide with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Balsalazide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
