相互作用
Baricitinib + Penicillin g procaine-penicillin g
重症度: 中等度
Baricitinib and Penicillin g procaine-penicillin g: moderate interaction.
最終更新日
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概要
Penicillin G is eliminated by renal tubular secretion and can inhibit OAT3, the transporter involved in baricitinib clearance. This may raise baricitinib exposure, although the clinical effect is probably modest.
この相互作用をわかりやすく説明すると
Baricitinib and Penicillin g procaine-penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baricitinib belongs to Musculoskeletal; Penicillin g procaine-penicillin g belongs to Anti Bacterial.
なぜ起こるのか
Inhibition of renal OAT3-mediated tubular secretion of baricitinib by penicillin G reduces its elimination.
対処法
Monitor for baricitinib adverse effects such as infection and cytopenias during penicillin courses. Dose reduction is generally not needed for short courses of penicillin.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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アカウントを作成してPro+トライアルを始めると、BaricitinibとPenicillin g procaine-penicillin gの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Penicillin g procaine-penicillin gのその他の相互作用
- Amifampridine + Penicillin g procaine-penicillin g 中等度
- Cholera vaccine + Penicillin g procaine-penicillin g 中等度
- Microbiota + Penicillin g procaine-penicillin g 中等度
- Omadacycline + Penicillin g procaine-penicillin g 中等度
- Penicillin g procaine-penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid 中等度
- Penicillin g procaine-penicillin g + Vadadustat 中等度
Baricitinibのその他の相互作用
よくある質問
Can I take Baricitinib with Penicillin g procaine-penicillin g?
MediHelp rates the interaction as moderate. Baricitinib and Penicillin g procaine-penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Penicillin G is eliminated by renal tubular secretion and can inhibit OAT3, the transporter involved in baricitinib clearance. This may raise baricitinib exposure, although the clinical effect is probably modest.
How serious is the interaction between Baricitinib and Penicillin g procaine-penicillin g?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for baricitinib adverse effects such as infection and cytopenias during penicillin courses. Dose reduction is generally not needed for short courses of penicillin.
What other medicines interact with Penicillin g procaine-penicillin g?
MediHelp also lists interactions of Penicillin g procaine-penicillin g with, for example, Amifampridine, Cholera vaccine, Microbiota. The full list is on the Penicillin g procaine-penicillin g page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
