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相互作用

Bazedoxifene-conjugated estrogens + Ospemifene

重症度: 併用禁忌

Bazedoxifene-conjugated estrogens and Ospemifene: contraindicated interaction.

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概要

Both are estrogen agonist/antagonist agents with estrogenic effects on the endometrium and venous thromboembolism risk. Combining them adds duplicate therapy and additive risk of thromboembolic events and endometrial effects without benefit.

この相互作用をわかりやすく説明すると

Bazedoxifene-conjugated estrogens and Ospemifene are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Bazedoxifene-conjugated estrogens belongs to Endocrine; Ospemifene belongs to Endocrine.

エビデンスレベル: Moderate

なぜ起こるのか

Additive pharmacodynamic estrogen-receptor modulation with duplicated prothrombotic and endometrial effects.

対処法

Do not use together; choose one agent for menopausal symptoms.

薬剤師に尋ねること

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+会員向け

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アカウントを作成してPro+トライアルを始めると、Bazedoxifene-conjugated estrogensとOspemifeneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

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よくある質問

Can I take Bazedoxifene-conjugated estrogens with Ospemifene?

MediHelp rates the interaction as contraindicated. Bazedoxifene-conjugated estrogens and Ospemifene are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are estrogen agonist/antagonist agents with estrogenic effects on the endometrium and venous thromboembolism risk. Combining them adds duplicate therapy and additive risk of thromboembolic events and endometrial effects without benefit.

How serious is the interaction between Bazedoxifene-conjugated estrogens and Ospemifene?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose one agent for menopausal symptoms.

What other medicines interact with Bazedoxifene-conjugated estrogens?

MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Antithrombin alfa, Antithrombin iii. The full list is on the Bazedoxifene-conjugated estrogens page.

完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで

MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。

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