相互作用
Ospemifene + Rifampicin
重症度: 重大
Ospemifene and Rifampicin: major interaction.
最終更新日
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概要
Rifampicin considerably lowers ospemifene exposure, which may reduce its effect on dyspareunia and vaginal dryness.
この相互作用をわかりやすく説明すると
Ospemifene and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ospemifene belongs to Endocrine; Rifampicin belongs to Anti Bacterial.
なぜ起こるのか
Induction of CYP3A4, CYP2C9 and CYP2C19 by rifampicin increases ospemifene clearance.
対処法
Do not use together; choose an alternative therapy if rifampicin is required.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、OspemifeneとRifampicinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ospemifeneのその他の相互作用
Rifampicinのその他の相互作用
よくある質問
Can I take Ospemifene with Rifampicin?
MediHelp rates the interaction as major. Ospemifene and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin considerably lowers ospemifene exposure, which may reduce its effect on dyspareunia and vaginal dryness.
How serious is the interaction between Ospemifene and Rifampicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose an alternative therapy if rifampicin is required.
What other medicines interact with Ospemifene?
MediHelp also lists interactions of Ospemifene with, for example, Bazedoxifene-conjugated estrogens, Estradiol, Clomiphene. The full list is on the Ospemifene page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
