相互作用
Bcg vaccine live + Deflazacort
重症度: 併用禁忌
Bcg vaccine live and Deflazacort: contraindicated interaction.
最終更新日
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概要
Deflazacort suppresses cellular immunity, so the live attenuated BCG organism may replicate unchecked and cause local or disseminated BCG infection. Vaccine response may also be blunted, leaving the patient inadequately protected.
この相互作用をわかりやすく説明すると
Bcg vaccine live and Deflazacort are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Glucocorticoid-induced immunosuppression impairs control of the live attenuated organism and reduces the immune response to the vaccine.
対処法
Do not give BCG to patients on immunosuppressive doses of deflazacort; defer vaccination until corticosteroid therapy has been stopped for the interval stated in the product labeling. Use an alternative preventive strategy if protection is needed urgently.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Bcg vaccine liveとDeflazacortの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Deflazacortのその他の相互作用
- Adenovirus types 4 and 7 live + Deflazacort 併用禁忌
- Deflazacort + Influenza virus vaccine quadrivalent intranasal 併用禁忌
- Deflazacort + Measles mumps and rubella vaccine 併用禁忌
- Deflazacort + Measles mumps and rubella vaccine live 併用禁忌
- Deflazacort + Measles mumps rubella and varicella vaccine live 併用禁忌
- Deflazacort + Measles vaccine 併用禁忌
よくある質問
Can I take Bcg vaccine live with Deflazacort?
MediHelp rates the interaction as contraindicated. Bcg vaccine live and Deflazacort are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Deflazacort suppresses cellular immunity, so the live attenuated BCG organism may replicate unchecked and cause local or disseminated BCG infection. Vaccine response may also be blunted, leaving the patient inadequately protected.
How serious is the interaction between Bcg vaccine live and Deflazacort?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give BCG to patients on immunosuppressive doses of deflazacort; defer vaccination until corticosteroid therapy has been stopped for the interval stated in the product labeling. Use an alternative preventive strategy if protection is needed urgently.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Deflazacort page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
