相互作用
Benzathine penicillin g + Ceftobiprole medocaril
重症度: 軽度
Benzathine penicillin g and Ceftobiprole medocaril: minor interaction.
最終更新日
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概要
Ceftobiprole inhibits hepatic uptake transporters OATP1B1 and OATP1B3 and could raise exposure to substrates. Penicillin G is not a clinically important OATP substrate and has a wide therapeutic index, so a meaningful effect is not expected.
この相互作用をわかりやすく説明すると
Benzathine penicillin g and Ceftobiprole medocaril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
なぜ起こるのか
Possible inhibition of OATP1B1/1B3-mediated uptake by ceftobiprole; relevance for penicillin G is theoretical.
対処法
No dose adjustment is needed. Be aware of the potential effect and watch for penicillin adverse effects such as hypersensitivity or neurotoxicity in patients with renal impairment.
薬剤師に尋ねること
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Benzathine penicillin gとCeftobiprole medocarilの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Benzathine penicillin gのその他の相互作用
よくある質問
Can I take Benzathine penicillin g with Ceftobiprole medocaril?
MediHelp rates the interaction as minor. Benzathine penicillin g and Ceftobiprole medocaril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ceftobiprole inhibits hepatic uptake transporters OATP1B1 and OATP1B3 and could raise exposure to substrates. Penicillin G is not a clinically important OATP substrate and has a wide therapeutic index, so a meaningful effect is not expected.
How serious is the interaction between Benzathine penicillin g and Ceftobiprole medocaril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Be aware of the potential effect and watch for penicillin adverse effects such as hypersensitivity or neurotoxicity in patients with renal impairment.
What other medicines interact with Benzathine penicillin g?
MediHelp also lists interactions of Benzathine penicillin g with, for example, Cholera vaccine, Microbiota, Omadacycline. The full list is on the Benzathine penicillin g page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
