Drug interactions
Benzathine penicillin g + Ceftobiprole medocaril
Severity: Minor
Benzathine penicillin g and Ceftobiprole medocaril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftobiprole inhibits hepatic uptake transporters OATP1B1 and OATP1B3 and could raise exposure to substrates. Penicillin G is not a clinically important OATP substrate and has a wide therapeutic index, so a meaningful effect is not expected.
What this interaction means in plain words
Benzathine penicillin g and Ceftobiprole medocaril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of OATP1B1/1B3-mediated uptake by ceftobiprole; relevance for penicillin G is theoretical.
What to do
No dose adjustment is needed. Be aware of the potential effect and watch for penicillin adverse effects such as hypersensitivity or neurotoxicity in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Benzathine penicillin g
- Benzathine penicillin g + Cholera vaccine Moderate
- Benzathine penicillin g + Microbiota Moderate
- Benzathine penicillin g + Omadacycline Moderate
- Benzathine penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Amifampridine + Benzathine penicillin g Minor
Frequently asked questions
Can I take Benzathine penicillin g with Ceftobiprole medocaril?
MediHelp rates the interaction as minor. Benzathine penicillin g and Ceftobiprole medocaril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ceftobiprole inhibits hepatic uptake transporters OATP1B1 and OATP1B3 and could raise exposure to substrates. Penicillin G is not a clinically important OATP substrate and has a wide therapeutic index, so a meaningful effect is not expected.
How serious is the interaction between Benzathine penicillin g and Ceftobiprole medocaril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Be aware of the potential effect and watch for penicillin adverse effects such as hypersensitivity or neurotoxicity in patients with renal impairment.
What other medicines interact with Benzathine penicillin g?
MediHelp also lists interactions of Benzathine penicillin g with, for example, Cholera vaccine, Microbiota, Omadacycline. The full list is on the Benzathine penicillin g page.
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