相互作用
Daprodustat + Gemfibrozil
重症度: 併用禁忌
Daprodustat and Gemfibrozil: contraindicated interaction.
最終更新日
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概要
Gemfibrozil and its glucuronide strongly inhibit CYP2C8, the main enzyme clearing daprodustat, causing a marked rise in daprodustat exposure. This increases the risk of excessive erythropoiesis and thrombotic events, and labeling contraindicates the combination.
この相互作用をわかりやすく説明すると
Daprodustat and Gemfibrozil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Daprodustat belongs to Endocrine; Gemfibrozil belongs to Cardiovascular.
なぜ起こるのか
Strong CYP2C8 inhibition by gemfibrozil and its glucuronide metabolite reduces daprodustat clearance.
対処法
Do not coadminister; use a different lipid-lowering agent such as a statin or fenofibrate. Monitor hemoglobin if exposure occurs.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DaprodustatとGemfibrozilの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Gemfibrozilのその他の相互作用
Daprodustatのその他の相互作用
よくある質問
Can I take Daprodustat with Gemfibrozil?
MediHelp rates the interaction as contraindicated. Daprodustat and Gemfibrozil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Gemfibrozil and its glucuronide strongly inhibit CYP2C8, the main enzyme clearing daprodustat, causing a marked rise in daprodustat exposure. This increases the risk of excessive erythropoiesis and thrombotic events, and labeling contraindicates the combination.
How serious is the interaction between Daprodustat and Gemfibrozil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use a different lipid-lowering agent such as a statin or fenofibrate. Monitor hemoglobin if exposure occurs.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Elagolix, Mavacamten, Metformin-repaglinide. The full list is on the Gemfibrozil page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
