相互作用
Bosentan + Levonorgestrel
重症度: 重大
Bosentan and Levonorgestrel: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Bosentan induces CYP3A4 and may lower systemic levonorgestrel exposure from oral or emergency products. The intrauterine system acts mainly locally and is much less affected, so the concern is mainly for systemic formulations, and bosentan is teratogenic.
この相互作用をわかりやすく説明すると
Bosentan and Levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosentan belongs to Miscellaneous; Levonorgestrel belongs to Endocrine.
なぜ起こるのか
Bosentan induces CYP3A4, increasing the metabolism of levonorgestrel.
対処法
Use a reliable method that does not depend on systemic hormone levels, such as an intrauterine system or copper IUD, rather than oral levonorgestrel alone. Consider a higher emergency contraception dose or a copper IUD for emergency use.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BosentanとLevonorgestrelの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Levonorgestrelのその他の相互作用
Bosentanのその他の相互作用
よくある質問
Can I take Bosentan with Levonorgestrel?
MediHelp rates the interaction as major. Bosentan and Levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bosentan induces CYP3A4 and may lower systemic levonorgestrel exposure from oral or emergency products. The intrauterine system acts mainly locally and is much less affected, so the concern is mainly for systemic formulations, and bosentan is teratogenic.
How serious is the interaction between Bosentan and Levonorgestrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reliable method that does not depend on systemic hormone levels, such as an intrauterine system or copper IUD, rather than oral levonorgestrel alone. Consider a higher emergency contraception dose or a copper IUD for emergency use.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
