相互作用
Brigatinib + Levonorgestrel
重症度: 重大
Brigatinib and Levonorgestrel: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Brigatinib may lower hormonal contraceptive concentrations and lead to loss of contraceptive efficacy. Pregnancy during brigatinib therapy is a concern because of fetal harm.
この相互作用をわかりやすく説明すると
Brigatinib and Levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brigatinib belongs to Oncology; Levonorgestrel belongs to Endocrine.
なぜ起こるのか
Brigatinib induces CYP3A4, accelerating levonorgestrel metabolism.
対処法
Use an effective non-hormonal contraceptive during treatment and for at least 4 months after the last dose.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BrigatinibとLevonorgestrelの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Levonorgestrelのその他の相互作用
Brigatinibのその他の相互作用
よくある質問
Can I take Brigatinib with Levonorgestrel?
MediHelp rates the interaction as major. Brigatinib and Levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brigatinib may lower hormonal contraceptive concentrations and lead to loss of contraceptive efficacy. Pregnancy during brigatinib therapy is a concern because of fetal harm.
How serious is the interaction between Brigatinib and Levonorgestrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an effective non-hormonal contraceptive during treatment and for at least 4 months after the last dose.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
