相互作用
Bosutinib + Diltiazem
重症度: 重大
Bosutinib and Diltiazem: major interaction.
最終更新日
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概要
Bosutinib is a CYP3A4 substrate, and diltiazem is a moderate CYP3A4 inhibitor. Higher bosutinib levels raise the risk of hepatotoxicity, gastrointestinal toxicity and myelosuppression.
この相互作用をわかりやすく説明すると
Bosutinib and Diltiazem can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosutinib belongs to Oncology; Diltiazem belongs to Cardiovascular.
なぜ起こるのか
Diltiazem inhibits CYP3A4-mediated metabolism of bosutinib.
対処法
Avoid the combination and use a non-interacting alternative to diltiazem. If it is unavoidable, monitor liver tests, blood counts and GI symptoms and consider reducing the bosutinib dose.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BosutinibとDiltiazemの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Diltiazemのその他の相互作用
Bosutinibのその他の相互作用
よくある質問
Can I take Bosutinib with Diltiazem?
MediHelp rates the interaction as major. Bosutinib and Diltiazem can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bosutinib is a CYP3A4 substrate, and diltiazem is a moderate CYP3A4 inhibitor. Higher bosutinib levels raise the risk of hepatotoxicity, gastrointestinal toxicity and myelosuppression.
How serious is the interaction between Bosutinib and Diltiazem?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-interacting alternative to diltiazem. If it is unavoidable, monitor liver tests, blood counts and GI symptoms and consider reducing the bosutinib dose.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
