相互作用
Bosutinib + Nizatidine
重症度: 中等度
Bosutinib and Nizatidine: moderate interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Bosutinib solubility falls as gastric pH rises, so acid-reducing agents can lower its absorption. This may reduce efficacy in leukemia treatment.
この相互作用をわかりやすく説明すると
Bosutinib and Nizatidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Nizatidine belongs to Gastrointestinal Tract.
なぜ起こるのか
Nizatidine increases gastric pH, reducing pH-dependent dissolution and absorption of bosutinib.
対処法
Consider short-acting antacids separated from bosutinib by at least 2 hours, or an alternative to the H2 blocker.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BosutinibとNizatidineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Nizatidineのその他の相互作用
Bosutinibのその他の相互作用
よくある質問
Can I take Bosutinib with Nizatidine?
MediHelp rates the interaction as moderate. Bosutinib and Nizatidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosutinib solubility falls as gastric pH rises, so acid-reducing agents can lower its absorption. This may reduce efficacy in leukemia treatment.
How serious is the interaction between Bosutinib and Nizatidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider short-acting antacids separated from bosutinib by at least 2 hours, or an alternative to the H2 blocker.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Dasatinib, Erlotinib. The full list is on the Nizatidine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
