相互作用
Dasatinib + Nizatidine
重症度: 重大
Dasatinib and Nizatidine: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Dasatinib absorption depends on an acidic gastric environment, and H2 blockers raise gastric pH. Exposure to dasatinib may fall, risking reduced antileukemic efficacy.
この相互作用をわかりやすく説明すると
Dasatinib and Nizatidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Nizatidine belongs to Gastrointestinal Tract.
なぜ起こるのか
Reduced pH-dependent dissolution and absorption of dasatinib due to gastric acid suppression.
対処法
Avoid H2 blockers with dasatinib; use short-acting antacids instead, given about 2 hours before or after dasatinib.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DasatinibとNizatidineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Nizatidineのその他の相互作用
Dasatinibのその他の相互作用
よくある質問
Can I take Dasatinib with Nizatidine?
MediHelp rates the interaction as major. Dasatinib and Nizatidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dasatinib absorption depends on an acidic gastric environment, and H2 blockers raise gastric pH. Exposure to dasatinib may fall, risking reduced antileukemic efficacy.
How serious is the interaction between Dasatinib and Nizatidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid H2 blockers with dasatinib; use short-acting antacids instead, given about 2 hours before or after dasatinib.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Erlotinib, Itraconazole. The full list is on the Nizatidine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
