相互作用
Ketoconazole + Nizatidine
重症度: 重大
Ketoconazole and Nizatidine: major interaction.
最終更新日
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概要
Ketoconazole requires an acidic stomach for dissolution and absorption. Nizatidine can substantially reduce ketoconazole exposure and lead to antifungal failure.
この相互作用をわかりやすく説明すると
Ketoconazole and Nizatidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketoconazole belongs to Anti Fungals; Nizatidine belongs to Gastrointestinal Tract.
なぜ起こるのか
Elevated gastric pH decreases dissolution and absorption of ketoconazole.
対処法
Avoid the combination where possible, or use an alternative antifungal. If unavoidable, give ketoconazole at least 2 hours before nizatidine.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、KetoconazoleとNizatidineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Nizatidineのその他の相互作用
Ketoconazoleのその他の相互作用
よくある質問
Can I take Ketoconazole with Nizatidine?
MediHelp rates the interaction as major. Ketoconazole and Nizatidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketoconazole requires an acidic stomach for dissolution and absorption. Nizatidine can substantially reduce ketoconazole exposure and lead to antifungal failure.
How serious is the interaction between Ketoconazole and Nizatidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use an alternative antifungal. If unavoidable, give ketoconazole at least 2 hours before nizatidine.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Dasatinib, Erlotinib. The full list is on the Nizatidine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
