相互作用
Brentuximab vedotin + Isoniazid
重症度: 中等度
Brentuximab vedotin and Isoniazid: moderate interaction.
最終更新日
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概要
The cytotoxic component of brentuximab vedotin, MMAE, is metabolized by CYP3A4, so CYP3A4 inhibitors can raise its exposure and the risk of neutropenia. Isoniazid is only a weak inhibitor, so any effect is likely modest. Isoniazid also adds neuropathy and hepatotoxicity risk.
この相互作用をわかりやすく説明すると
Brentuximab vedotin and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab vedotin belongs to Oncology; Isoniazid belongs to Anti Bacterial.
なぜ起こるのか
Possible weak CYP3A4 inhibition by isoniazid increasing MMAE exposure, with additive neurotoxicity.
対処法
Monitor blood counts for neutropenia and for peripheral neuropathy. Give pyridoxine as per isoniazid practice.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Brentuximab vedotinとIsoniazidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Isoniazidのその他の相互作用
Brentuximab vedotinのその他の相互作用
よくある質問
Can I take Brentuximab vedotin with Isoniazid?
MediHelp rates the interaction as moderate. Brentuximab vedotin and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The cytotoxic component of brentuximab vedotin, MMAE, is metabolized by CYP3A4, so CYP3A4 inhibitors can raise its exposure and the risk of neutropenia. Isoniazid is only a weak inhibitor, so any effect is likely modest. Isoniazid also adds neuropathy and hepatotoxicity risk.
How serious is the interaction between Brentuximab vedotin and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts for neutropenia and for peripheral neuropathy. Give pyridoxine as per isoniazid practice.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
