相互作用
Bumetanide + Carbenoxolone
重症度: 重大
Bumetanide and Carbenoxolone: major interaction.
最終更新日
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概要
Carbenoxolone has mineralocorticoid-like activity causing sodium retention and potassium loss, which adds to bumetanide-induced hypokalemia. Severe hypokalemia can cause arrhythmias and muscle weakness, and the sodium retention may oppose the diuretic effect.
この相互作用をわかりやすく説明すると
Bumetanide and Carbenoxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive renal potassium wasting, with carbenoxolone causing mineralocorticoid-like sodium retention through inhibition of 11-beta-hydroxysteroid dehydrogenase.
対処法
Avoid the combination where possible, or monitor serum potassium closely and replace potassium as required. Consider a potassium-sparing diuretic if both drugs must be continued.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BumetanideとCarbenoxoloneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Bumetanideのその他の相互作用
よくある質問
Can I take Bumetanide with Carbenoxolone?
MediHelp rates the interaction as major. Bumetanide and Carbenoxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbenoxolone has mineralocorticoid-like activity causing sodium retention and potassium loss, which adds to bumetanide-induced hypokalemia. Severe hypokalemia can cause arrhythmias and muscle weakness, and the sodium retention may oppose the diuretic effect.
How serious is the interaction between Bumetanide and Carbenoxolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor serum potassium closely and replace potassium as required. Consider a potassium-sparing diuretic if both drugs must be continued.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
