相互作用
Bumetanide + Cisplatin
重症度: 重大
Bumetanide and Cisplatin: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Both drugs can damage the inner ear, and combined use may increase the risk or severity of hearing loss and tinnitus. Loop diuretic-induced volume depletion may also worsen cisplatin nephrotoxicity.
この相互作用をわかりやすく説明すると
Bumetanide and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bumetanide belongs to Cardiovascular; Cisplatin belongs to Oncology.
なぜ起こるのか
Additive ototoxicity via cochlear hair cell injury, with possible added renal toxicity from volume depletion.
対処法
Avoid bumetanide where possible during cisplatin therapy; if needed, use the lowest dose, maintain hydration, and monitor hearing and renal function.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BumetanideとCisplatinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Bumetanideのその他の相互作用
Cisplatinのその他の相互作用
よくある質問
Can I take Bumetanide with Cisplatin?
MediHelp rates the interaction as major. Bumetanide and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can damage the inner ear, and combined use may increase the risk or severity of hearing loss and tinnitus. Loop diuretic-induced volume depletion may also worsen cisplatin nephrotoxicity.
How serious is the interaction between Bumetanide and Cisplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid bumetanide where possible during cisplatin therapy; if needed, use the lowest dose, maintain hydration, and monitor hearing and renal function.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
