相互作用
Bumetanide + Digoxin
重症度: 重大
Bumetanide and Digoxin: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Bumetanide-induced hypokalemia and hypomagnesemia increase myocardial sensitivity to digoxin and can precipitate digoxin toxicity and arrhythmias. This is clinically important in heart failure patients who commonly take both.
この相互作用をわかりやすく説明すると
Bumetanide and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bumetanide belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
なぜ起こるのか
Loop diuretic potassium and magnesium depletion enhances digoxin binding to Na+/K+-ATPase and arrhythmogenicity.
対処法
Monitor serum potassium and magnesium regularly and keep them in the normal range with replacement as needed. Check digoxin levels and renal function if toxicity symptoms occur.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BumetanideとDigoxinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Bumetanideのその他の相互作用
Digoxinのその他の相互作用
よくある質問
Can I take Bumetanide with Digoxin?
MediHelp rates the interaction as major. Bumetanide and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bumetanide-induced hypokalemia and hypomagnesemia increase myocardial sensitivity to digoxin and can precipitate digoxin toxicity and arrhythmias. This is clinically important in heart failure patients who commonly take both.
How serious is the interaction between Bumetanide and Digoxin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and keep them in the normal range with replacement as needed. Check digoxin levels and renal function if toxicity symptoms occur.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
