相互作用
Bumetanide + Captopril-hydrochlorothiazide
重症度: 重大
Bumetanide and Captopril-hydrochlorothiazide: major interaction.
最終更新日
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概要
Combining a loop diuretic with a thiazide produces sequential nephron blockade, causing marked diuresis, hypokalemia, hyponatremia, hypomagnesemia and volume depletion. With captopril, hypotension and acute kidney injury are more likely.
この相互作用をわかりやすく説明すると
Bumetanide and Captopril-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bumetanide belongs to Cardiovascular; Captopril-hydrochlorothiazide belongs to Cardiovascular.
なぜ起こるのか
Additive natriuresis and potassium wasting at different nephron sites, with volume depletion potentiating ACE inhibitor hypotension and renal effects.
対処法
Monitor electrolytes, creatinine, weight and blood pressure closely, particularly in the first weeks. Reduce diuretic doses or replace potassium and magnesium as needed.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BumetanideとCaptopril-hydrochlorothiazideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Captopril-hydrochlorothiazideのその他の相互作用
Bumetanideのその他の相互作用
よくある質問
Can I take Bumetanide with Captopril-hydrochlorothiazide?
MediHelp rates the interaction as major. Bumetanide and Captopril-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a loop diuretic with a thiazide produces sequential nephron blockade, causing marked diuresis, hypokalemia, hyponatremia, hypomagnesemia and volume depletion. With captopril, hypotension and acute kidney injury are more likely.
How serious is the interaction between Bumetanide and Captopril-hydrochlorothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, creatinine, weight and blood pressure closely, particularly in the first weeks. Reduce diuretic doses or replace potassium and magnesium as needed.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
