相互作用
Bupivacaine liposome + Lidocaine
重症度: 重大
Bupivacaine liposome and Lidocaine: major interaction.
最終更新日
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概要
Non-bupivacaine local anesthetics such as lidocaine can disrupt the liposomal formulation and release free bupivacaine rapidly. This eliminates the prolonged-release profile and may increase the risk of systemic bupivacaine toxicity. Labeling advises against mixing and recommends a delay after lidocaine.
この相互作用をわかりやすく説明すると
Bupivacaine liposome and Lidocaine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Lidocaine alters the liposomal carrier, causing rapid release of unencapsulated bupivacaine.
対処法
Do not mix the products in the same syringe. If lidocaine is used first, wait at least 20 minutes before infiltrating bupivacaine liposome.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Bupivacaine liposomeとLidocaineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Lidocaineのその他の相互作用
よくある質問
Can I take Bupivacaine liposome with Lidocaine?
MediHelp rates the interaction as major. Bupivacaine liposome and Lidocaine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Non-bupivacaine local anesthetics such as lidocaine can disrupt the liposomal formulation and release free bupivacaine rapidly. This eliminates the prolonged-release profile and may increase the risk of systemic bupivacaine toxicity. Labeling advises against mixing and recommends a delay after lidocaine.
How serious is the interaction between Bupivacaine liposome and Lidocaine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not mix the products in the same syringe. If lidocaine is used first, wait at least 20 minutes before infiltrating bupivacaine liposome.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells, Nirmatrelvir / ritonavir. The full list is on the Lidocaine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
