相互作用
Lidocaine + Pimozide
重症度: 重大
Lidocaine and Pimozide: major interaction.
最終更新日
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概要
Systemic lidocaine, such as intravenous use as an antiarrhythmic, may add to the QT-prolonging and proarrhythmic potential of pimozide. Pimozide is a high-risk QT-prolonging drug and torsades de pointes is a concern. Local anesthetic use gives minimal systemic exposure and is less relevant.
この相互作用をわかりやすく説明すると
Lidocaine and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lidocaine belongs to Cardiovascular; Pimozide belongs to Central Nervous System.
なぜ起こるのか
Additive cardiac electrophysiologic effects with pimozide-related QT prolongation.
対処法
Avoid systemic lidocaine with pimozide if possible, or monitor ECG continuously and keep potassium and magnesium normal. Prefer minimal doses for local anesthesia.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LidocaineとPimozideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Lidocaineのその他の相互作用
Pimozideのその他の相互作用
よくある質問
Can I take Lidocaine with Pimozide?
MediHelp rates the interaction as major. Lidocaine and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic lidocaine, such as intravenous use as an antiarrhythmic, may add to the QT-prolonging and proarrhythmic potential of pimozide. Pimozide is a high-risk QT-prolonging drug and torsades de pointes is a concern. Local anesthetic use gives minimal systemic exposure and is less relevant.
How serious is the interaction between Lidocaine and Pimozide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic lidocaine with pimozide if possible, or monitor ECG continuously and keep potassium and magnesium normal. Prefer minimal doses for local anesthesia.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
