相互作用
Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir
重症度: 重大
Lidocaine and Ombitasvir / paritaprevir / ritonavir and dasabuvir: major interaction.
最終更新日
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概要
Ritonavir is a strong CYP3A4 inhibitor, and paritaprevir adds to this effect, which reduces lidocaine clearance. Systemic lidocaine concentrations can rise, causing CNS toxicity and arrhythmia. The label advises caution with antiarrhythmics given with this regimen.
この相互作用をわかりやすく説明すると
Lidocaine and Ombitasvir / paritaprevir / ritonavir and dasabuvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Ritonavir and paritaprevir inhibit CYP3A4 metabolism of lidocaine.
対処法
Avoid systemic lidocaine if possible, or reduce the dose and monitor ECG and lidocaine concentrations. Single local anaesthetic doses may be acceptable with observation.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LidocaineとOmbitasvir / paritaprevir / ritonavir and dasabuvirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Lidocaineのその他の相互作用
よくある質問
Can I take Lidocaine with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as major. Lidocaine and Ombitasvir / paritaprevir / ritonavir and dasabuvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir is a strong CYP3A4 inhibitor, and paritaprevir adds to this effect, which reduces lidocaine clearance. Systemic lidocaine concentrations can rise, causing CNS toxicity and arrhythmia. The label advises caution with antiarrhythmics given with this regimen.
How serious is the interaction between Lidocaine and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic lidocaine if possible, or reduce the dose and monitor ECG and lidocaine concentrations. Single local anaesthetic doses may be acceptable with observation.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
