相互作用
Buprenorphine + Selpercatinib
重症度: 重大
Buprenorphine and Selpercatinib: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes. The risk is greater with electrolyte disturbances, bradycardia or underlying heart disease.
この相互作用をわかりやすく説明すると
Buprenorphine and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Buprenorphine belongs to Musculoskeletal; Selpercatinib belongs to Oncology.
なぜ起こるのか
Additive prolongation of cardiac repolarization through potassium channel effects.
対処法
Obtain a baseline ECG and correct potassium and magnesium before starting, then monitor the QTc periodically. Consider an alternative analgesic if the QTc becomes markedly prolonged.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BuprenorphineとSelpercatinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Buprenorphineのその他の相互作用
Selpercatinibのその他の相互作用
よくある質問
Can I take Buprenorphine with Selpercatinib?
MediHelp rates the interaction as major. Buprenorphine and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes. The risk is greater with electrolyte disturbances, bradycardia or underlying heart disease.
How serious is the interaction between Buprenorphine and Selpercatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before starting, then monitor the QTc periodically. Consider an alternative analgesic if the QTc becomes markedly prolonged.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
