相互作用
Amiodarone + Selpercatinib
重症度: 重大
Amiodarone and Selpercatinib: major interaction.
最終更新日
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概要
Both drugs can prolong the QT interval, so giving them together may increase the risk of torsades de pointes. The risk is greater with electrolyte disturbances, bradycardia or structural heart disease.
この相互作用をわかりやすく説明すると
Amiodarone and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Selpercatinib belongs to Oncology.
なぜ起こるのか
Additive pharmacodynamic QT prolongation through cardiac repolarization effects.
対処法
Obtain a baseline and follow-up ECG and correct potassium, magnesium and calcium before and during treatment. Consider an alternative antiarrhythmic, or reduce or interrupt selpercatinib if QTc becomes markedly prolonged.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmiodaroneとSelpercatinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amiodaroneのその他の相互作用
Selpercatinibのその他の相互作用
よくある質問
Can I take Amiodarone with Selpercatinib?
MediHelp rates the interaction as major. Amiodarone and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so giving them together may increase the risk of torsades de pointes. The risk is greater with electrolyte disturbances, bradycardia or structural heart disease.
How serious is the interaction between Amiodarone and Selpercatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline and follow-up ECG and correct potassium, magnesium and calcium before and during treatment. Consider an alternative antiarrhythmic, or reduce or interrupt selpercatinib if QTc becomes markedly prolonged.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
