相互作用
Amisulpride + Selpercatinib
重症度: 重大
Amisulpride and Selpercatinib: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Selpercatinib can prolong the QT interval and amisulpride adds further QT risk. The pair may provoke serious ventricular arrhythmias.
この相互作用をわかりやすく説明すると
Amisulpride and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Selpercatinib belongs to Oncology.
なぜ起こるのか
Additive QT prolongation.
対処法
Avoid if an alternative exists. Otherwise monitor ECG and electrolytes at baseline and periodically, and correct abnormalities.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmisulprideとSelpercatinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Amisulprideのその他の相互作用
Selpercatinibのその他の相互作用
よくある質問
Can I take Amisulpride with Selpercatinib?
MediHelp rates the interaction as major. Amisulpride and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Selpercatinib can prolong the QT interval and amisulpride adds further QT risk. The pair may provoke serious ventricular arrhythmias.
How serious is the interaction between Amisulpride and Selpercatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative exists. Otherwise monitor ECG and electrolytes at baseline and periodically, and correct abnormalities.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
