相互作用
Bupropion + Selegiline transdermal
重症度: 併用禁忌
Bupropion and Selegiline transdermal: contraindicated interaction.
最終更新日
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概要
Combining bupropion with a monoamine oxidase inhibitor can cause hypertensive reactions due to increased catecholamine levels. The label contraindicates this combination.
この相互作用をわかりやすく説明すると
Bupropion and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Bupropion inhibits dopamine and norepinephrine reuptake while MAO inhibition reduces their breakdown, producing additive catecholaminergic effects.
対処法
Do not coadminister. Allow at least 14 days between stopping the MAOI and starting bupropion, and likewise when switching in the other direction.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BupropionとSelegiline transdermalの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Bupropionのその他の相互作用
よくある質問
Can I take Bupropion with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Bupropion and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining bupropion with a monoamine oxidase inhibitor can cause hypertensive reactions due to increased catecholamine levels. The label contraindicates this combination.
How serious is the interaction between Bupropion and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Allow at least 14 days between stopping the MAOI and starting bupropion, and likewise when switching in the other direction.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
