相互作用
Bupropion + Thioridazine
重症度: 併用禁忌
Bupropion and Thioridazine: contraindicated interaction.
最終更新日
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概要
Thioridazine is metabolised by CYP2D6, and bupropion is a strong inhibitor of this enzyme. Higher thioridazine levels can cause marked QT prolongation and torsades de pointes. Thioridazine labeling contraindicates drugs that inhibit its metabolism.
この相互作用をわかりやすく説明すると
Bupropion and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bupropion belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
なぜ起こるのか
Bupropion inhibits CYP2D6, raising thioridazine levels and QT prolongation risk.
対処法
Do not combine; use an alternative antidepressant or antipsychotic. If exposure occurs, obtain an ECG and check potassium and magnesium.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BupropionとThioridazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Bupropionのその他の相互作用
Thioridazineのその他の相互作用
よくある質問
Can I take Bupropion with Thioridazine?
MediHelp rates the interaction as contraindicated. Bupropion and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine is metabolised by CYP2D6, and bupropion is a strong inhibitor of this enzyme. Higher thioridazine levels can cause marked QT prolongation and torsades de pointes. Thioridazine labeling contraindicates drugs that inhibit its metabolism.
How serious is the interaction between Bupropion and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use an alternative antidepressant or antipsychotic. If exposure occurs, obtain an ECG and check potassium and magnesium.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
