相互作用
Butorphanol + Clobazam
重症度: 重大
Butorphanol and Clobazam: major interaction.
最終更新日
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概要
Opioids combined with benzodiazepines such as clobazam cause additive sedation and respiratory depression, and may lead to coma or death.
この相互作用をわかりやすく説明すると
Butorphanol and Clobazam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Butorphanol belongs to Musculoskeletal; Clobazam belongs to Central Nervous System.
なぜ起こるのか
Additive CNS and respiratory depression via opioid receptors and enhanced GABA-A receptor signalling.
対処法
Reserve concurrent use for patients without alternatives, using the lowest doses and shortest duration. Monitor respiratory rate and sedation closely.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ButorphanolとClobazamの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Butorphanolのその他の相互作用
Clobazamのその他の相互作用
よくある質問
Can I take Butorphanol with Clobazam?
MediHelp rates the interaction as major. Butorphanol and Clobazam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with benzodiazepines such as clobazam cause additive sedation and respiratory depression, and may lead to coma or death.
How serious is the interaction between Butorphanol and Clobazam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve concurrent use for patients without alternatives, using the lowest doses and shortest duration. Monitor respiratory rate and sedation closely.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
