相互作用
Clobazam + Clozapine
重症度: 重大
Clobazam and Clozapine: major interaction.
最終更新日
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概要
Both agents depress the CNS, so combining them can cause excessive sedation, and benzodiazepines with clozapine have been associated with respiratory depression and collapse. The risk is highest at initiation or after dose increases.
この相互作用をわかりやすく説明すると
Clobazam and Clozapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clobazam belongs to Central Nervous System; Clozapine belongs to Central Nervous System.
なぜ起こるのか
Additive CNS and respiratory depression through GABA-A potentiation and clozapine's sedative actions.
対処法
Use the lowest effective doses and titrate slowly, monitoring sedation, blood pressure and respiratory status. Avoid starting both together.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClobazamとClozapineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clozapineのその他の相互作用
Clobazamのその他の相互作用
よくある質問
Can I take Clobazam with Clozapine?
MediHelp rates the interaction as major. Clobazam and Clozapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents depress the CNS, so combining them can cause excessive sedation, and benzodiazepines with clozapine have been associated with respiratory depression and collapse. The risk is highest at initiation or after dose increases.
How serious is the interaction between Clobazam and Clozapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and titrate slowly, monitoring sedation, blood pressure and respiratory status. Avoid starting both together.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
