相互作用
Chloral hydrate + Clobazam
重症度: 重大
Chloral hydrate and Clobazam: major interaction.
最終更新日
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概要
Clobazam is a benzodiazepine, and combining it with chloral hydrate increases sedation and the risk of respiratory depression. Impaired cognition and falls are more likely in older or frail patients.
この相互作用をわかりやすく説明すると
Chloral hydrate and Clobazam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloral hydrate belongs to Central Nervous System; Clobazam belongs to Central Nervous System.
なぜ起こるのか
Additive CNS depression through enhanced GABAergic inhibition.
対処法
Avoid concurrent use where possible; otherwise use the lowest effective doses and monitor sedation and respiratory function. Caution against alcohol and other depressants.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Chloral hydrateとClobazamの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Chloral hydrateのその他の相互作用
Clobazamのその他の相互作用
よくある質問
Can I take Chloral hydrate with Clobazam?
MediHelp rates the interaction as major. Chloral hydrate and Clobazam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clobazam is a benzodiazepine, and combining it with chloral hydrate increases sedation and the risk of respiratory depression. Impaired cognition and falls are more likely in older or frail patients.
How serious is the interaction between Chloral hydrate and Clobazam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; otherwise use the lowest effective doses and monitor sedation and respiratory function. Caution against alcohol and other depressants.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
