相互作用
Caffeine + Pefloxacin
重症度: 中等度
Caffeine and Pefloxacin: moderate interaction.
最終更新日
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概要
Pefloxacin inhibits caffeine metabolism and reduces its clearance, raising caffeine levels and half-life. This may cause jitteriness, insomnia, tachycardia and, at high intake, seizures or arrhythmias.
この相互作用をわかりやすく説明すると
Caffeine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Caffeine belongs to Miscellaneous; Pefloxacin belongs to Anti Bacterial.
なぜ起こるのか
Inhibition of CYP1A2-mediated caffeine metabolism by pefloxacin.
対処法
Advise patients to reduce caffeine intake while taking pefloxacin and watch for tremor, insomnia, palpitations or agitation.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CaffeineとPefloxacinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Caffeineのその他の相互作用
Pefloxacinのその他の相互作用
よくある質問
Can I take Caffeine with Pefloxacin?
MediHelp rates the interaction as moderate. Caffeine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pefloxacin inhibits caffeine metabolism and reduces its clearance, raising caffeine levels and half-life. This may cause jitteriness, insomnia, tachycardia and, at high intake, seizures or arrhythmias.
How serious is the interaction between Caffeine and Pefloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to reduce caffeine intake while taking pefloxacin and watch for tremor, insomnia, palpitations or agitation.
What other medicines interact with Caffeine?
MediHelp also lists interactions of Caffeine with, for example, Ephedrine, Fezolinetant, Methylenedioxymethamphetamine. The full list is on the Caffeine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
