相互作用
Clozapine + Pefloxacin
重症度: 重大
Clozapine and Pefloxacin: major interaction.
最終更新日
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概要
Pefloxacin inhibits CYP1A2 and can raise clozapine concentrations, increasing the risk of sedation, hypotension, seizures, myocarditis and QT effects. Fluoroquinolones also have their own QT and seizure-lowering effects.
この相互作用をわかりやすく説明すると
Clozapine and Pefloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Pefloxacin belongs to Anti Bacterial.
なぜ起こるのか
Pefloxacin inhibits CYP1A2, decreasing clozapine clearance.
対処法
Prefer an antibiotic that does not inhibit CYP1A2. If it must be used, reduce the clozapine dose and monitor clinical toxicity, clozapine levels and ECG.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClozapineとPefloxacinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clozapineのその他の相互作用
Pefloxacinのその他の相互作用
よくある質問
Can I take Clozapine with Pefloxacin?
MediHelp rates the interaction as major. Clozapine and Pefloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pefloxacin inhibits CYP1A2 and can raise clozapine concentrations, increasing the risk of sedation, hypotension, seizures, myocarditis and QT effects. Fluoroquinolones also have their own QT and seizure-lowering effects.
How serious is the interaction between Clozapine and Pefloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antibiotic that does not inhibit CYP1A2. If it must be used, reduce the clozapine dose and monitor clinical toxicity, clozapine levels and ECG.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
