相互作用
Carboprost tromethamine + Oxytocin
重症度: 重大
Carboprost tromethamine and Oxytocin: major interaction.
最終更新日
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概要
Carboprost and oxytocin both stimulate uterine contraction, and used together their effects are potentiated. This is sometimes done deliberately for postpartum hemorrhage, but it raises the risk of uterine hypertonus and, before delivery, uterine rupture.
この相互作用をわかりやすく説明すると
Carboprost tromethamine and Oxytocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive uterotonic effect through prostaglandin F2-alpha receptor and oxytocin receptor stimulation.
対処法
Use together only under obstetric supervision with continuous monitoring of uterine tone and fetal status where relevant. Avoid in the antepartum setting unless clearly indicated.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Carboprost tromethamineとOxytocinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Oxytocinのその他の相互作用
よくある質問
Can I take Carboprost tromethamine with Oxytocin?
MediHelp rates the interaction as major. Carboprost tromethamine and Oxytocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carboprost and oxytocin both stimulate uterine contraction, and used together their effects are potentiated. This is sometimes done deliberately for postpartum hemorrhage, but it raises the risk of uterine hypertonus and, before delivery, uterine rupture.
How serious is the interaction between Carboprost tromethamine and Oxytocin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only under obstetric supervision with continuous monitoring of uterine tone and fetal status where relevant. Avoid in the antepartum setting unless clearly indicated.
What other medicines interact with Oxytocin?
MediHelp also lists interactions of Oxytocin with, for example, Dinoprostone, Ephedrine, Fexinidazole. The full list is on the Oxytocin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
