相互作用
Givinostat + Oxytocin
重症度: 重大
Givinostat and Oxytocin: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Givinostat can prolong the QT interval and oxytocin has been associated with QT prolongation, so the effects may add together. This raises the risk of ventricular arrhythmia, especially with electrolyte disturbances.
この相互作用をわかりやすく説明すると
Givinostat and Oxytocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Givinostat belongs to Miscellaneous; Oxytocin belongs to Endocrine.
なぜ起こるのか
Additive pharmacodynamic QT prolongation.
対処法
Avoid if possible; otherwise obtain ECGs at initiation and during co-use, correct electrolytes, and withhold the offending drug if QTc becomes markedly prolonged.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、GivinostatとOxytocinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Oxytocinのその他の相互作用
Givinostatのその他の相互作用
よくある質問
Can I take Givinostat with Oxytocin?
MediHelp rates the interaction as major. Givinostat and Oxytocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Givinostat can prolong the QT interval and oxytocin has been associated with QT prolongation, so the effects may add together. This raises the risk of ventricular arrhythmia, especially with electrolyte disturbances.
How serious is the interaction between Givinostat and Oxytocin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise obtain ECGs at initiation and during co-use, correct electrolytes, and withhold the offending drug if QTc becomes markedly prolonged.
What other medicines interact with Oxytocin?
MediHelp also lists interactions of Oxytocin with, for example, Carboprost tromethamine, Dinoprostone, Ephedrine. The full list is on the Oxytocin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
