相互作用
Cefadroxil + Kanamycin
重症度: 中等度
Cefadroxil and Kanamycin: moderate interaction.
最終更新日
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概要
Aminoglycosides are nephrotoxic and ototoxic, and cephalosporins have occasionally been reported to add to renal injury when combined with them. Cefadroxil has little intrinsic nephrotoxicity, so the added risk is modest but matters in patients with reduced renal function. Both drugs are renally eliminated, so impairment raises exposure to each.
この相互作用をわかりやすく説明すると
Cefadroxil and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
なぜ起こるのか
Additive renal tubular injury, with reduced renal clearance of both drugs when kidney function declines.
対処法
Monitor serum creatinine and aminoglycoside levels, and adjust doses to renal function. Ensure hydration and watch for hearing or balance changes.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CefadroxilとKanamycinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cefadroxilのその他の相互作用
よくある質問
Can I take Cefadroxil with Kanamycin?
MediHelp rates the interaction as moderate. Cefadroxil and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides are nephrotoxic and ototoxic, and cephalosporins have occasionally been reported to add to renal injury when combined with them. Cefadroxil has little intrinsic nephrotoxicity, so the added risk is modest but matters in patients with reduced renal function. Both drugs are renally eliminated, so impairment raises exposure to each.
How serious is the interaction between Cefadroxil and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and aminoglycoside levels, and adjust doses to renal function. Ensure hydration and watch for hearing or balance changes.
What other medicines interact with Cefadroxil?
MediHelp also lists interactions of Cefadroxil with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefadroxil page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
