相互作用
Cefepime + Gentamicin
重症度: 中等度
Cefepime and Gentamicin: moderate interaction.
最終更新日
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概要
Both are given intravenously and both are cleared by the kidney, and gentamicin also carries ototoxicity risk. Cefepime is not strongly nephrotoxic, but renal decline raises exposure to both drugs, increasing gentamicin toxicity and cefepime neurotoxicity.
この相互作用をわかりやすく説明すると
Cefepime and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefepime belongs to Anti Bacterial; Gentamicin belongs to Anti Bacterial.
なぜ起こるのか
Possible additive renal effects; both drugs are renally cleared, so declining renal function raises exposure to each.
対処法
Monitor serum creatinine and gentamicin levels, and adjust the doses of both drugs to renal function. Watch for confusion or myoclonus from cefepime accumulation and for hearing changes.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CefepimeとGentamicinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cefepimeのその他の相互作用
Gentamicinのその他の相互作用
よくある質問
Can I take Cefepime with Gentamicin?
MediHelp rates the interaction as moderate. Cefepime and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are given intravenously and both are cleared by the kidney, and gentamicin also carries ototoxicity risk. Cefepime is not strongly nephrotoxic, but renal decline raises exposure to both drugs, increasing gentamicin toxicity and cefepime neurotoxicity.
How serious is the interaction between Cefepime and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin levels, and adjust the doses of both drugs to renal function. Watch for confusion or myoclonus from cefepime accumulation and for hearing changes.
What other medicines interact with Cefepime?
MediHelp also lists interactions of Cefepime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefepime page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
