相互作用
Cefoxitin + Gentamicin
重症度: 中等度
Cefoxitin and Gentamicin: moderate interaction.
最終更新日
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概要
Concurrent use of a cephalosporin with an aminoglycoside has been associated with additive kidney injury in some reports, particularly in patients with other risk factors. Aminoglycoside ototoxicity may also be a concern with prolonged exposure. The effect is generally manageable.
この相互作用をわかりやすく説明すると
Cefoxitin and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefoxitin belongs to Anti Bacterial; Gentamicin belongs to Anti Bacterial.
なぜ起こるのか
Additive nephrotoxic potential, with aminoglycoside tubular toxicity possibly being aggravated by cephalosporins.
対処法
Monitor serum creatinine and gentamicin trough levels during combined therapy, and keep the aminoglycoside course as short as possible. Ensure adequate hydration and avoid other nephrotoxins.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CefoxitinとGentamicinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cefoxitinのその他の相互作用
Gentamicinのその他の相互作用
よくある質問
Can I take Cefoxitin with Gentamicin?
MediHelp rates the interaction as moderate. Cefoxitin and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of a cephalosporin with an aminoglycoside has been associated with additive kidney injury in some reports, particularly in patients with other risk factors. Aminoglycoside ototoxicity may also be a concern with prolonged exposure. The effect is generally manageable.
How serious is the interaction between Cefoxitin and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin trough levels during combined therapy, and keep the aminoglycoside course as short as possible. Ensure adequate hydration and avoid other nephrotoxins.
What other medicines interact with Cefoxitin?
MediHelp also lists interactions of Cefoxitin with, for example, Amikacin, Aztreonam, Bcg vaccine live. The full list is on the Cefoxitin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
