相互作用
Charcoal + Digoxin
重症度: 中等度
Charcoal and Digoxin: moderate interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Activated charcoal adsorbs oral digoxin and interrupts its enterohepatic recirculation, lowering serum levels. This is helpful in digoxin toxicity but can reduce efficacy if given at therapeutic doses.
この相互作用をわかりやすく説明すると
Charcoal and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Charcoal belongs to Gastrointestinal Tract; Digoxin belongs to Cardiovascular.
なぜ起こるのか
Charcoal binds digoxin in the gut, decreasing absorption and enterohepatic recycling.
対処法
Avoid charcoal in routine therapy or separate it from digoxin by several hours. In digoxin poisoning, charcoal is appropriate along with digoxin-specific antibody fragments and monitoring of levels and potassium.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CharcoalとDigoxinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Charcoalのその他の相互作用
Digoxinのその他の相互作用
よくある質問
Can I take Charcoal with Digoxin?
MediHelp rates the interaction as moderate. Charcoal and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Activated charcoal adsorbs oral digoxin and interrupts its enterohepatic recirculation, lowering serum levels. This is helpful in digoxin toxicity but can reduce efficacy if given at therapeutic doses.
How serious is the interaction between Charcoal and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid charcoal in routine therapy or separate it from digoxin by several hours. In digoxin poisoning, charcoal is appropriate along with digoxin-specific antibody fragments and monitoring of levels and potassium.
What other medicines interact with Charcoal?
MediHelp also lists interactions of Charcoal with, for example, Citalopram, Leflunomide, Methotrexate. The full list is on the Charcoal page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
