相互作用
Chenodeoxycholic acid + Phenobarbitone
重症度: 中等度
Chenodeoxycholic acid and Phenobarbitone: moderate interaction.
最終更新日
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概要
Phenobarbital can induce HMG-CoA reductase and bile acid synthesis, which may counteract the intended suppression of abnormal bile acid production by chenodeoxycholic acid. Therapeutic effect may be reduced.
この相互作用をわかりやすく説明すると
Chenodeoxycholic acid and Phenobarbitone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chenodeoxycholic acid belongs to Gastrointestinal Tract; Phenobarbitone belongs to Central Nervous System.
なぜ起こるのか
Enzyme induction by phenobarbital increases cholesterol and bile acid synthesis, opposing chenodeoxycholic acid feedback inhibition.
対処法
Monitor urinary or serum bile alcohols and adjust the chenodeoxycholic acid dose as needed. Consider a non-inducing anticonvulsant if appropriate.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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アカウントを作成してPro+トライアルを始めると、Chenodeoxycholic acidとPhenobarbitoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Chenodeoxycholic acidのその他の相互作用
Phenobarbitoneのその他の相互作用
よくある質問
Can I take Chenodeoxycholic acid with Phenobarbitone?
MediHelp rates the interaction as moderate. Chenodeoxycholic acid and Phenobarbitone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital can induce HMG-CoA reductase and bile acid synthesis, which may counteract the intended suppression of abnormal bile acid production by chenodeoxycholic acid. Therapeutic effect may be reduced.
How serious is the interaction between Chenodeoxycholic acid and Phenobarbitone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary or serum bile alcohols and adjust the chenodeoxycholic acid dose as needed. Consider a non-inducing anticonvulsant if appropriate.
What other medicines interact with Chenodeoxycholic acid?
MediHelp also lists interactions of Chenodeoxycholic acid with, for example, Cyclosporin, Sirolimus, Aluminum hydroxide. The full list is on the Chenodeoxycholic acid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
