Drug interactions
Chenodeoxycholic acid + Phenobarbitone
Severity: Moderate
Chenodeoxycholic acid and Phenobarbitone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital can induce HMG-CoA reductase and bile acid synthesis, which may counteract the intended suppression of abnormal bile acid production by chenodeoxycholic acid. Therapeutic effect may be reduced.
What this interaction means in plain words
Chenodeoxycholic acid and Phenobarbitone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chenodeoxycholic acid belongs to Gastrointestinal Tract; Phenobarbitone belongs to Central Nervous System.
Why it happens
Enzyme induction by phenobarbital increases cholesterol and bile acid synthesis, opposing chenodeoxycholic acid feedback inhibition.
What to do
Monitor urinary or serum bile alcohols and adjust the chenodeoxycholic acid dose as needed. Consider a non-inducing anticonvulsant if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chenodeoxycholic acid
Other interactions of Phenobarbitone
- Cabotegravir + Phenobarbitone Contraindicated
- Doravirine + Phenobarbitone Contraindicated
- Isavuconazole + Phenobarbitone Contraindicated
- Darolutamide + Phenobarbitone Major
- Finerenone + Phenobarbitone Major
- Ivacaftor + Phenobarbitone Major
Frequently asked questions
Can I take Chenodeoxycholic acid with Phenobarbitone?
MediHelp rates the interaction as moderate. Chenodeoxycholic acid and Phenobarbitone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital can induce HMG-CoA reductase and bile acid synthesis, which may counteract the intended suppression of abnormal bile acid production by chenodeoxycholic acid. Therapeutic effect may be reduced.
How serious is the interaction between Chenodeoxycholic acid and Phenobarbitone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary or serum bile alcohols and adjust the chenodeoxycholic acid dose as needed. Consider a non-inducing anticonvulsant if appropriate.
What other medicines interact with Chenodeoxycholic acid?
MediHelp also lists interactions of Chenodeoxycholic acid with, for example, Cyclosporin, Sirolimus, Aluminum hydroxide. The full list is on the Chenodeoxycholic acid page.
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