相互作用
Chloramphenicol + Erdafitinib
重症度: 重大
Chloramphenicol and Erdafitinib: major interaction.
最終更新日
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概要
Erdafitinib is metabolized by CYP2C9 and CYP3A4, and inhibition of these pathways can raise its exposure. This may increase hyperphosphatemia, ocular and dermatologic toxicity, and stomatitis.
この相互作用をわかりやすく説明すると
Chloramphenicol and Erdafitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Erdafitinib belongs to Oncology.
なぜ起こるのか
Chloramphenicol inhibits CYP3A4 and CYP2C9, reducing erdafitinib clearance.
対処法
Use an alternative antibiotic if possible. If coadministered, monitor closely for adverse reactions and consider reducing the erdafitinib dose, and re-escalate after the inhibitor is stopped if no toxicity.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ChloramphenicolとErdafitinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Chloramphenicolのその他の相互作用
Erdafitinibのその他の相互作用
よくある質問
Can I take Chloramphenicol with Erdafitinib?
MediHelp rates the interaction as major. Chloramphenicol and Erdafitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erdafitinib is metabolized by CYP2C9 and CYP3A4, and inhibition of these pathways can raise its exposure. This may increase hyperphosphatemia, ocular and dermatologic toxicity, and stomatitis.
How serious is the interaction between Chloramphenicol and Erdafitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic if possible. If coadministered, monitor closely for adverse reactions and consider reducing the erdafitinib dose, and re-escalate after the inhibitor is stopped if no toxicity.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
