相互作用
Chloramphenicol + Pralsetinib
重症度: 重大
Chloramphenicol and Pralsetinib: major interaction.
最終更新日
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概要
Pralsetinib is cleared by CYP3A4, and chloramphenicol may increase its exposure. This may heighten adverse effects such as hepatotoxicity, hypertension, pneumonitis and myelosuppression.
この相互作用をわかりやすく説明すると
Chloramphenicol and Pralsetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Pralsetinib belongs to Oncology.
なぜ起こるのか
Chloramphenicol inhibits CYP3A4, reducing pralsetinib clearance.
対処法
Avoid the combination where possible. If required, reduce the pralsetinib dose per labeling for CYP3A4 inhibitors and monitor liver tests and blood counts.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ChloramphenicolとPralsetinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Chloramphenicolのその他の相互作用
Pralsetinibのその他の相互作用
よくある質問
Can I take Chloramphenicol with Pralsetinib?
MediHelp rates the interaction as major. Chloramphenicol and Pralsetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pralsetinib is cleared by CYP3A4, and chloramphenicol may increase its exposure. This may heighten adverse effects such as hepatotoxicity, hypertension, pneumonitis and myelosuppression.
How serious is the interaction between Chloramphenicol and Pralsetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If required, reduce the pralsetinib dose per labeling for CYP3A4 inhibitors and monitor liver tests and blood counts.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
