相互作用
Chlorpromazine + Ibutilide
重症度: 併用禁忌
Chlorpromazine and Ibutilide: contraindicated interaction.
最終更新日
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概要
Both agents prolong repolarization, and ibutilide already carries a substantial risk of torsades de pointes. Adding chlorpromazine increases the likelihood of life-threatening ventricular arrhythmia.
この相互作用をわかりやすく説明すると
Chlorpromazine and Ibutilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Chlorpromazine belongs to Central Nervous System; Ibutilide belongs to Cardiovascular.
なぜ起こるのか
Additive QT prolongation from cardiac potassium channel blockade.
対処法
Avoid giving ibutilide to patients taking chlorpromazine; use an alternative cardioversion strategy or hold the phenothiazine as appropriate.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ChlorpromazineとIbutilideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Chlorpromazineのその他の相互作用
Ibutilideのその他の相互作用
よくある質問
Can I take Chlorpromazine with Ibutilide?
MediHelp rates the interaction as contraindicated. Chlorpromazine and Ibutilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents prolong repolarization, and ibutilide already carries a substantial risk of torsades de pointes. Adding chlorpromazine increases the likelihood of life-threatening ventricular arrhythmia.
How serious is the interaction between Chlorpromazine and Ibutilide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving ibutilide to patients taking chlorpromazine; use an alternative cardioversion strategy or hold the phenothiazine as appropriate.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
